Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfametomidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | HTR6 | P50406 | 5/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.61 |
| ▸ | PDE4A | P27815 | 1/20 | 0.57 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfametomidine SCHEMBL30336540 | 0.89 | HTR6 (0.76) | LMNAALDH1A1HTR6CYP3A4PDE4A | |
| Sulfametomidine SCHEMBL151238 | 0.89 | HTR6 (0.76) | LMNAALDH1A1HTR6CYP3A4PDE4A | |
| Sulfametomidine SCHEMBL11123046 | 0.88 | ALDH1A1 (0.74) | LMNAALDH1A1HTR6CYP3A4PDE4A | |
| Sulfameter SCHEMBL79417 | 0.84 | LMNA (1.00) | LMNAALDH1A1HTR6CYP3A4CYP2C19 | |
| Sulfameter SCHEMBL27709233 | 0.83 | LMNA (0.97) | LMNAALDH1A1HTR6CYP3A4CYP2C19 | |
| Sulfameter SCHEMBL11137116 | 0.83 | LMNA (0.97) | LMNAALDH1A1HTR6CYP3A4CYP2C19 | |
| Sulfameter SCHEMBL17593237 | 0.83 | LMNA (0.97) | LMNAALDH1A1HTR6CYP3A4CYP2C19 | |
| Sulfameter SCHEMBL7614372 | 0.82 | LMNA (0.81) | LMNAALDH1A1HTR6CYP3A4PDE4A | |
| Sulfametomidine SCHEMBL28142816 | 0.80 | KMT2A (0.71) | LMNAALDH1A1HTR6CYP3A4PDE4A | |
| SCHEMBL7833927 | 0.79 | HTR6 (0.72) | LMNAALDH1A1HTR6CYP3A4PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |
| EP-2699572-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| EP-2699579-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143144-A1 | PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |
| WO-2012143143-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |