Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | PHGDH | O43175 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17593159 | 0.87 | MAPT (0.48) | MAPTGAAALDH1A1LMNATP53 | |
| SCHEMBL17593242 | 0.80 | PHGDH (0.70) | ALDH1A1LMNAGRM4POLBKDM4E | |
| SCHEMBL26043608 | 0.78 | TNIK (0.51) | MAPTALDH1A1KMT2ABCHEACHE | |
| SCHEMBL17593002 | 0.78 | L3MBTL1 (0.46) | MAPTGAAALDH1A1LMNAGRM4 | |
| SCHEMBL21929513 | 0.76 | L3MBTL1 (0.55) | MAPTGAAALDH1A1LMNATP53 | |
| SCHEMBL4552859 | 0.75 | CDK1 (0.57) | ALDH1A1LMNAAURKAKDRFLT3 | |
| SCHEMBL17593003 | 0.75 | KMT2A (0.67) | MAPTGAAALDH1A1LMNATP53 | |
| SCHEMBL8690975 | 0.74 | KMT2A (0.57) | MAPTPOLBMEN1KMT2A | |
| SCHEMBL13426353 | 0.73 | BCHE (0.56) | MAPTGAAALDH1A1LMNAKDR | |
| SCHEMBL17593165 | 0.72 | TRIM24 (0.49) | MAPTPOLBMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016040449-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | disclosed |