Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | IDE | P14735 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17593268 | 0.87 | MAPT (0.51) | MAPTGAATP53POLBMEN1 | |
| SCHEMBL29057737 | 0.79 | KMT2A (0.54) | MAPTTP53POLBMEN1KMT2A | |
| SCHEMBL15503777 | 0.76 | KMT2A (0.67) | MAPTGAAPOLBMEN1KMT2A | |
| SCHEMBL18499238 | 0.75 | MEN1 (0.54) | MAPTGAAMEN1KMT2ALMNA | |
| SCHEMBL17593148 | 0.74 | ADRB2 (0.44) | MAPTPOLBMEN1KMT2ATSHR | |
| SCHEMBL17593003 | 0.73 | KMT2A (0.67) | MAPTGAATP53MEN1KMT2A | |
| SCHEMBL17593267 | 0.69 | L3MBTL1 (0.57) | MAPTTP53POLBMEN1KMT2A | |
| SCHEMBL27181366 | 0.69 | GRM4 (0.74) | MAPTGAAPOLBMEN1KMT2A | |
| SCHEMBL30926458 | 0.69 | GRM4 (0.74) | MAPTGAAPOLBMEN1KMT2A | |
| SCHEMBL30926785 | 0.68 | GAA (0.74) | MAPTGAAPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016040449-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | disclosed |