Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 2/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31738006 | 0.72 | SLC6A4 (0.39) | NPC1RAB9AS1PR1SLC6A4SLC6A2 | |
| SCHEMBL2362735 | 0.72 | CHRNA4 (0.39) | NPC1RAB9ACHRNA4HPGDMEN1 | |
| SCHEMBL18167996 | 0.72 | ALDH1A1 (0.56) | NPC1RAB9ASLC6A4SLC6A2KCNH2 | |
| SCHEMBL31738175 | 0.71 | KDM4E (0.40) | NPC1RAB9AS1PR1SLC6A4SLC6A2 | |
| SCHEMBL3809371 | 0.71 | SLC6A4 (0.51) | SLC6A4SLC6A2KCNH2HPGDTSHR | |
| SCHEMBL14611173 | 0.71 | MGLL (0.41) | NPC1RAB9AKCNH2MEN1KMT2A | |
| SCHEMBL17594578 | 0.70 | S1PR1 (0.41) | CHRNA4S1PR1SLC6A4SLC6A2MEN1 | |
| SCHEMBL562320 | 0.70 | POLB (0.53) | NPC1RAB9ASLC6A4SLC6A2KCNH2 | |
| SCHEMBL8366263 | 0.70 | MEN1 (0.55) | NPC1RAB9AS1PR1SLC6A4SLC6A2 | |
| SCHEMBL28630966 | 0.70 | POLB (0.46) | NPC1RAB9ASLC6A4SLC6A2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3193603-A1 | ISOXAZOLE CARBOXAMIDE COMPOUNDS | Epizyme, Inc. (US) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016040498-A1 | ISOXAZOLE CARBOXAMIDE COMPOUNDS | Epizyme, Inc. (US) | 2016-03-17 | — | — | WO | disclosed |