SCHEMBL17595155

SCHEMBL17595155

c1ccc(CSc2nc(N(Cc3ccccc3)Cc3ccccc3)nc3c2ncn3Cc2ccccc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.67
CYP3A4 P08684 2/20 0.67
CYP2C9 P11712 2/20 0.67
CYP2C19 P33261 2/20 0.67
HIF1A Q16665 2/20 0.67
ALDH1A1 P00352 1/20 0.67
PHLPP2 Q6ZVD8 1/20 0.67
SLC29A1 Q99808 6/20 0.50
CDK1 P06493 1/20 0.43
PNP P00491 1/20 0.43
YTHDC1 Q96MU7 1/20 0.43
CYP2D6 P10635 1/20 0.43
PDE4A P27815 2/20 0.42
PDE4B Q07343 2/20 0.42
PDE4C Q08493 2/20 0.42
PDE4D Q08499 2/20 0.42
PDE3B Q13370 1/20 0.42
PDE3A Q14432 1/20 0.42
ADORA2A P29274 1/20 0.41
PI4KA P42356 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17595248 0.81 CYP1A2 (1.00) CYP1A2CYP3A4CYP2C9CYP2C19HIF1A
SCHEMBL17595442 0.78 CYP1A2 (0.69) CYP1A2CYP3A4CYP2C9CYP2C19HIF1A
SCHEMBL7209433 0.71 ALDH1A1 (0.66) CYP1A2CYP3A4CYP2C9CYP2C19HIF1A
SCHEMBL7211257 0.69 PDE4A (0.58) CYP1A2CYP3A4CYP2C9CYP2C19HIF1A
SCHEMBL5460049 0.67 HSP90AA1 (0.49) YTHDC1ADORA2A
SCHEMBL7204383 0.67 PDE4A (0.62) CYP1A2CYP3A4CYP2C9CYP2C19HIF1A
SCHEMBL2965769 0.67 SLC29A1 (1.00) SLC29A1
SCHEMBL31732889 0.66 CYP1A2 (0.53) CYP1A2CYP3A4CYP2C9CYP2C19HIF1A
SCHEMBL5045749 0.66 SLC29A1 (0.64) CYP1A2CYP3A4CYP2C9CYP2C19HIF1A
SCHEMBL183057 0.65 YTHDC1 (0.68) CYP1A2CYP3A4CYP2C9CYP2C19HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016038562-A1 THIOGUANINE DERIVATIVES MALAYSIAN INSTITUTE OF PHARMACEUTICALS AND NUTRACEUTICALS (MY) 2016-03-17 WO claimed
WO-2016038562-A1 THIOGUANINE DERIVATIVES MALAYSIAN INSTITUTE OF PHARMACEUTICALS AND NUTRACEUTICALS (MY) 2016-03-17 WO disclosed