Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 17/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21253552 | 0.85 | P2RX7 (0.43) | P2RX7 | |
| SCHEMBL20099682 | 0.85 | P2RX7 (0.43) | P2RX7 | |
| SCHEMBL17596616 | 0.80 | P2RX7 (0.76) | P2RX7 | |
| SCHEMBL17596615 | 0.80 | P2RX7 (0.76) | P2RX7 | |
| SCHEMBL12905247 | 0.71 | P2RX7 (0.48) | P2RX7KDM4EALDH1A1HPGD | |
| SCHEMBL17595651 | 0.68 | P2RX7 (0.75) | P2RX7 | |
| SCHEMBL17596191 | 0.67 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL17596480 | 0.67 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL17596272 | 0.67 | P2RX7 (0.86) | P2RX7 | |
| SCHEMBL17595636 | 0.66 | P2RX7 (1.00) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191488-A1 | P2X7 MODULATING N-ACYL-TRIAZOLOPYRAZINES | Janssen Pharmaceutica, N.V. (BE) | 2017-07-19 | — | — | EP | disclosed |
| WO-2016039983-A1 | P2X7 MODULATING N-ACYL-TRIAZOLOPYRAZINES | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-17 | — | — | WO | disclosed |