Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 17/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21253552 | 1.00 | P2RX7 (0.43) | P2RX7ABCB1GPR119ADORA2AADORA1 | |
| SCHEMBL17596294 | 0.85 | P2RX7 (0.50) | P2RX7 | |
| SCHEMBL30980030 | 0.80 | P2RX7 (0.56) | P2RX7ABCB1GPR119ADORA2AADORA1 | |
| SCHEMBL17596276 | 0.79 | P2RX7 (0.59) | P2RX7 | |
| SCHEMBL17596277 | 0.79 | P2RX7 (0.59) | P2RX7 | |
| SCHEMBL17596464 | 0.77 | P2RX7 (0.52) | P2RX7GPR119 | |
| SCHEMBL17596463 | 0.77 | P2RX7 (0.52) | P2RX7GPR119 | |
| SCHEMBL17596300 | 0.76 | P2RX7 (0.64) | P2RX7GPR119 | |
| SCHEMBL17596299 | 0.76 | P2RX7 (0.64) | P2RX7GPR119 | |
| SCHEMBL17596616 | 0.75 | P2RX7 (0.76) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191488-B1 | P2X7 MODULATING N-ACYL-TRIAZOLOPYRAZINES | JANSSEN PHARMACEUTICA NV (BE) | 2019-08-14 | — | — | EP | disclosed |
| US-20180118749-A1 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-03 | — | — | US | disclosed |
| US-20180118749-A1 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118749-A1 | P2X7 MODULATORS | P2RX7, P2RX3, P2RX1 | P2RX7 1/4885ABCB1 154/4885GPR119 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.