Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 17/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20099682 | 1.00 | P2RX7 (0.43) | P2RX7ABCB1GPR119ADORA2AADORA1 | |
| SCHEMBL17596294 | 0.85 | P2RX7 (0.50) | P2RX7 | |
| SCHEMBL30980030 | 0.80 | P2RX7 (0.56) | P2RX7ABCB1GPR119ADORA2AADORA1 | |
| SCHEMBL17596276 | 0.79 | P2RX7 (0.59) | P2RX7 | |
| SCHEMBL17596277 | 0.79 | P2RX7 (0.59) | P2RX7 | |
| SCHEMBL17596464 | 0.77 | P2RX7 (0.52) | P2RX7GPR119 | |
| SCHEMBL17596463 | 0.77 | P2RX7 (0.52) | P2RX7GPR119 | |
| SCHEMBL17596300 | 0.76 | P2RX7 (0.64) | P2RX7GPR119 | |
| SCHEMBL17596299 | 0.76 | P2RX7 (0.64) | P2RX7GPR119 | |
| SCHEMBL17596616 | 0.75 | P2RX7 (0.76) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191488-B1 | P2X7 MODULATING N-ACYL-TRIAZOLOPYRAZINES | JANSSEN PHARMACEUTICA NV (BE) | 2019-08-14 | — | — | EP | disclosed |