Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 16/20 | 0.64 |
| ▸ | TACR3 | P29371 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17596300 | 1.00 | P2RX7 (0.64) | P2RX7TACR3GPR119CCR1CCR5 | |
| SCHEMBL16027635 | 0.82 | P2RX7 (0.59) | P2RX7 | |
| SCHEMBL16027633 | 0.82 | P2RX7 (0.59) | P2RX7 | |
| SCHEMBL20099705 | 0.78 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL17595605 | 0.78 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL17595604 | 0.78 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL21253552 | 0.76 | P2RX7 (0.43) | P2RX7GPR119 | |
| SCHEMBL20099682 | 0.76 | P2RX7 (0.43) | P2RX7GPR119 | |
| SCHEMBL17596277 | 0.76 | P2RX7 (0.59) | P2RX7TACR3 | |
| SCHEMBL17596276 | 0.76 | P2RX7 (0.59) | P2RX7TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191488-A1 | P2X7 MODULATING N-ACYL-TRIAZOLOPYRAZINES | Janssen Pharmaceutica, N.V. (BE) | 2017-07-19 | — | — | EP | disclosed |
| WO-2016039983-A1 | P2X7 MODULATING N-ACYL-TRIAZOLOPYRAZINES | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-17 | — | — | WO | disclosed |