Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 6/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599328 | 0.84 | NR1H4 (0.53) | NPC1RAB9AMCL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL17613322 | 0.82 | RAB9A (0.44) | NPC1RAB9ANPY5RALDH1A1SMN1; SMN2 | |
| SCHEMBL17599301 | 0.78 | KMT2A (0.48) | MCL1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL17599351 | 0.73 | KMT2A (0.45) | NPC1RAB9AMCL1SMN1; SMN2MEN1 | |
| SCHEMBL17599371 | 0.73 | KMT2A (0.51) | MCL1ALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL17599404 | 0.73 | KMT2A (0.48) | MCL1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL17599389 | 0.72 | TDP1 (0.53) | NPC1RAB9AMCL1ALDH1A1KDM4E | |
| SCHEMBL17599329 | 0.72 | KMT2A (0.55) | MCL1ALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL26664991 | 0.71 | POLB (0.52) | NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL26657089 | 0.71 | POLB (0.59) | KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |