Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.48 |
| ▸ | G6PD | P11413 | 1/20 | 0.48 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.48 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | FABP4 | P15090 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ACLY | P53396 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599340 | 0.90 | SLC16A3 (0.58) | KMT2AMEN1SERPINE1SLC16A3USP2 | |
| SCHEMBL17599360 | 0.88 | ITGA1 (0.56) | KMT2AMEN1SERPINE1SLC16A3MCL1 | |
| SCHEMBL17599371 | 0.86 | KMT2A (0.51) | KMT2AMEN1SLC16A3MCL1HTT | |
| SCHEMBL17599301 | 0.85 | KMT2A (0.48) | KMT2AMEN1GAARAD52G6PD | |
| SCHEMBL17599333 | 0.85 | PTK2B (0.52) | KMT2AMEN1GAARAD52G6PD | |
| SCHEMBL17599403 | 0.84 | WDR5 (0.49) | KMT2AMEN1SLC16A3MCL1FABP4 | |
| SCHEMBL17599368 | 0.82 | KDM4E (0.48) | KMT2AMEN1SERPINE1SLC16A3MCL1 | |
| SCHEMBL17599379 | 0.82 | ACLY (0.54) | KMT2AMEN1SLC16A3FABP4ACLY | |
| SCHEMBL17599382 | 0.82 | WDR5 (0.45) | KMT2AMEN1SERPINE1SLC16A3MCL1 | |
| SCHEMBL17599353 | 0.82 | ACLY (0.58) | KMT2ASERPINE1MCL1ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |