Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | G6PD | P11413 | 1/20 | 0.48 |
| ▸ | CKS1B | P61024 | 1/20 | 0.47 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | IDH1 | O75874 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599404 | 0.85 | KMT2A (0.48) | KMT2AMEN1GAAG6PDRAD52 | |
| SCHEMBL17599328 | 0.85 | NR1H4 (0.53) | KMT2AMEN1GAAHTTCYP3A4 | |
| SCHEMBL17599371 | 0.79 | KMT2A (0.51) | KMT2AMEN1HTTALDH1A1NPSR1 | |
| SCHEMBL17599329 | 0.79 | KMT2A (0.55) | KMT2AMEN1ALDH1A1NR1H4MCL1 | |
| SCHEMBL17613345 | 0.78 | NR1H4 (0.44) | KMT2AMEN1CKS1BSKP2CYP3A4 | |
| SCHEMBL17599351 | 0.78 | KMT2A (0.45) | KMT2AMEN1MCL1 | |
| SCHEMBL17599403 | 0.78 | WDR5 (0.49) | KMT2AMEN1L3MBTL1MCL1 | |
| SCHEMBL17599376 | 0.78 | FABP4 (0.56) | KMT2AMEN1GAAG6PDRAD52 | |
| SCHEMBL17599348 | 0.78 | NPC1 (0.45) | KMT2AMEN1GAAHTTCYP3A4 | |
| SCHEMBL17599312 | 0.77 | KEAP1 (0.61) | KMT2AMEN1GAACKS1BSKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |