Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | ACLY | P53396 | 2/20 | 0.34 |
| ▸ | CMA1 | P23946 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599380 | 0.85 | MEN1 (0.44) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL17599409 | 0.83 | MEN1 (0.38) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL17599386 | 0.83 | MEN1 (0.37) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL17599321 | 0.72 | MCL1 (0.35) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL17599346 | 0.72 | CDC25B (0.45) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL17599329 | 0.70 | KMT2A (0.55) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL17599308 | 0.70 | FAAH (0.34) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL17599472 | 0.69 | ALDH1A1 (0.41) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL17599510 | 0.69 | KMT2A (0.53) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL17599363 | 0.68 | MEN1 (0.53) | KDM4EMEN1ALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |