Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2B | Q14289 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | FABP4 | P15090 | 5/20 | 0.48 |
| ▸ | ACLY | P53396 | 9/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599318 | 0.90 | ACLY (0.50) | PTK2BSMN1; SMN2L3MBTL1FABP4ACLY | |
| SCHEMBL17599399 | 0.90 | PTK2B (0.57) | PTK2BSMN1; SMN2L3MBTL1FABP4ACLY | |
| SCHEMBL17599333 | 0.87 | PTK2B (0.52) | PTK2BSMN1; SMN2L3MBTL1FABP4ACLY | |
| SCHEMBL17599374 | 0.87 | PTK2B (0.56) | PTK2BSMN1; SMN2L3MBTL1FABP4ACLY | |
| SCHEMBL17599371 | 0.84 | KMT2A (0.51) | PTK2BSMN1; SMN2L3MBTL1FABP4ACLY | |
| SCHEMBL17599300 | 0.84 | PTK2B (0.58) | PTK2BSMN1; SMN2FABP4ACLYFABP5 | |
| SCHEMBL17599315 | 0.82 | PTK2B (0.53) | PTK2BSMN1; SMN2FABP4ACLYFABP5 | |
| SCHEMBL17599370 | 0.82 | ALDH1A1 (0.53) | PTK2BSMN1; SMN2FABP4ACLYMEN1 | |
| SCHEMBL17599411 | 0.81 | TDP1 (0.55) | PTK2BSMN1; SMN2FABP4ACLYFABP5 | |
| SCHEMBL17599305 | 0.79 | ACLY (0.55) | PTK2BSMN1; SMN2L3MBTL1FABP4ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | claimed |
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |