Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 4/20 | 0.38 |
| ▸ | CMA1 | P23946 | 5/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599349 | 0.80 | MEN1 (0.43) | KEAP1SMN1; SMN2KDM4ETSHRTP53 | |
| SCHEMBL17599499 | 0.64 | KEAP1 (0.48) | KEAP1KDM4ETSHRTP53ALDH1A1 | |
| SCHEMBL16502691 | 0.63 | TP53 (0.46) | SMN1; SMN2KDM4ETSHRTP53ALDH1A1 | |
| SCHEMBL17599346 | 0.63 | CDC25B (0.45) | KEAP1SMN1; SMN2KDM4ETSHRALDH1A1 | |
| SCHEMBL17599324 | 0.63 | MEN1 (0.47) | KEAP1KDM4ETSHRTP53ALDH1A1 | |
| SCHEMBL20504366 | 0.62 | TP53 (0.55) | SMN1; SMN2KDM4ETSHRTP53ALDH1A1 | |
| SCHEMBL17599380 | 0.62 | MEN1 (0.44) | KEAP1CMA1CYP2C9SMN1; SMN2KDM4E | |
| SCHEMBL17110579 | 0.62 | NTRK1 (0.48) | SMN1; SMN2KDM4ETSHRTP53ALDH1A1 | |
| SCHEMBL14389382 | 0.62 | KDM4E (0.70) | CYP2C9SMN1; SMN2KDM4ETSHRALDH1A1 | |
| SCHEMBL16509474 | 0.62 | TP53 (0.42) | SMN1; SMN2KDM4ETSHRTP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |