Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 5/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599453 | 0.89 | KEAP1 (0.46) | KEAP1NFE2L2ALDH1A1MEN1KMT2A | |
| SCHEMBL17599527 | 0.84 | SLC6A3 (0.53) | KEAP1NFE2L2ALDH1A1MEN1KMT2A | |
| SCHEMBL17599324 | 0.76 | MEN1 (0.47) | KEAP1NFE2L2ALDH1A1MEN1KMT2A | |
| SCHEMBL17599551 | 0.74 | SLC6A2 (0.43) | KEAP1NFE2L2ALDH1A1MEN1KMT2A | |
| SCHEMBL17612857 | 0.72 | SLC6A3 (0.51) | ALDH1A1KDM4EHPGDHSD17B10SLC6A3 | |
| SCHEMBL17599346 | 0.71 | CDC25B (0.45) | KEAP1NFE2L2ALDH1A1MEN1KMT2A | |
| SCHEMBL17599329 | 0.71 | KMT2A (0.55) | KEAP1NFE2L2ALDH1A1MEN1KMT2A | |
| SCHEMBL17599363 | 0.71 | MEN1 (0.53) | KEAP1NFE2L2ALDH1A1MEN1KMT2A | |
| SCHEMBL17599477 | 0.71 | KEAP1 (0.59) | KEAP1NFE2L2ALDH1A1MEN1KMT2A | |
| SCHEMBL17599481 | 0.71 | KEAP1 (0.50) | KEAP1NFE2L2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997966-A1 | Naphthyl Sulfonamide Pyrrolidine Derivatives as KEAP-1 Modulators for the Treatment of Diabetes, Obesity, Dyslipidemia and Related Disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |