Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ACLY | P53396 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599370 | 0.84 | ALDH1A1 (0.53) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL17599373 | 0.84 | KMT2A (0.46) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL17599396 | 0.80 | KEAP1 (0.38) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL17599375 | 0.71 | ACLY (0.49) | MEN1KMT2AALDH1A1KDM4EKEAP1 | |
| SCHEMBL17599385 | 0.70 | TSHR (0.47) | KMT2ASMN1; SMN2FABP4PTK2BL3MBTL1 | |
| SCHEMBL17599305 | 0.70 | ACLY (0.55) | SMN1; SMN2FABP4PTK2BL3MBTL1ACLY | |
| SCHEMBL17599320 | 0.70 | SMN1; SMN2 (0.54) | MEN1KMT2AKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL17599329 | 0.70 | KMT2A (0.55) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL17599358 | 0.69 | ALDH1A1 (0.58) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL17599341 | 0.69 | FABP4 (0.43) | KMT2AALDH1A1HSD17B10KEAP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | claimed |
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |