Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB4 | Q16877 | 9/20 | 0.69 |
| ▸ | PFKFB3 | Q16875 | 9/20 | 0.69 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.57 |
| ▸ | CMA1 | P23946 | 5/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17613337 | 0.86 | PFKFB3 (0.63) | PFKFB4PFKFB3KEAP1CMA1NPSR1 | |
| SCHEMBL788108 | 0.82 | PFKFB4 (1.00) | PFKFB4PFKFB3CMA1NPSR1L3MBTL1 | |
| SCHEMBL27685 | 0.82 | PFKFB4 (0.66) | PFKFB4PFKFB3KEAP1CMA1NPSR1 | |
| SCHEMBL17599404 | 0.81 | KMT2A (0.48) | NPSR1L3MBTL1 | |
| SCHEMBL5621524 | 0.81 | PFKFB3 (0.70) | PFKFB4PFKFB3KEAP1CMA1NPSR1 | |
| SCHEMBL2157918 | 0.80 | PFKFB4 (0.66) | PFKFB4PFKFB3KEAP1CMA1NPSR1 | |
| Propane SCHEMBL28642185 | 0.80 | PFKFB4 (0.94) | PFKFB4PFKFB3CMA1NPSR1L3MBTL1 | |
| SCHEMBL17613341 | 0.79 | PFKFB4 (0.46) | PFKFB4PFKFB3KEAP1 | |
| SCHEMBL2912893 | 0.79 | CMA1 (0.82) | PFKFB4PFKFB3CMA1NPSR1L3MBTL1 | |
| SCHEMBL17599340 | 0.79 | SLC16A3 (0.58) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |