Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 4/20 | 0.74 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | CTSB | P07858 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | S100A4 | P26447 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599439 | 0.90 | KEAP1 (0.90) | KEAP1NFE2L2ALDH1A1CTSBMEN1 | |
| SCHEMBL17612852 | 0.88 | KEAP1 (0.71) | KEAP1NFE2L2NPSR1TSHRALDH1A1 | |
| SCHEMBL17599447 | 0.88 | KEAP1 (0.71) | KEAP1NFE2L2NPSR1TSHRALDH1A1 | |
| SCHEMBL17612859 | 0.88 | KEAP1 (0.71) | KEAP1NFE2L2NPSR1TSHRALDH1A1 | |
| SCHEMBL17599451 | 0.85 | KEAP1 (1.00) | KEAP1NFE2L2ALDH1A1CTSBMEN1 | |
| SCHEMBL17599418 | 0.85 | KEAP1 (1.00) | KEAP1NFE2L2ALDH1A1CTSBMEN1 | |
| SCHEMBL17612884 | 0.85 | KEAP1 (1.00) | KEAP1NFE2L2ALDH1A1CTSBMEN1 | |
| SCHEMBL17599548 | 0.79 | NPSR1 (0.53) | KEAP1NFE2L2NPSR1TSHRALDH1A1 | |
| SCHEMBL17599417 | 0.78 | KEAP1 (0.89) | KEAP1NFE2L2NPSR1TSHRALDH1A1 | |
| SCHEMBL17599488 | 0.78 | KEAP1 (0.89) | KEAP1NFE2L2NPSR1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997966-A1 | Naphthyl Sulfonamide Pyrrolidine Derivatives as KEAP-1 Modulators for the Treatment of Diabetes, Obesity, Dyslipidemia and Related Disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |