Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599472 | 0.87 | ALDH1A1 (0.41) | HPGDMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL17599467 | 0.81 | KMT2A (0.55) | HPGDMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL17613790 | 0.80 | HPGD (0.40) | HPGDMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL17599510 | 0.79 | KMT2A (0.53) | HPGDMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL17599435 | 0.78 | ALDH1A1 (0.57) | HPGDMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL17599466 | 0.78 | KMT2A (0.51) | HPGDMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL17599429 | 0.78 | KMT2A (0.51) | HPGDMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL17599423 | 0.77 | ALDH1A1 (0.56) | HPGDMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL17599483 | 0.77 | MEN1 (0.56) | HPGDMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL17599431 | 0.77 | KMT2A (0.50) | HPGDMEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998295-A1 | Aryl substituted naphthyl sulfonamide derivatives as keap-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | claimed |
| EP-2998295-A1 | Aryl substituted naphthyl sulfonamide derivatives as keap-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |
| EP-2998295-A1 | Aryl substituted naphthyl sulfonamide derivatives as keap-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |