Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 7/20 | 0.66 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17612856 | 0.93 | KEAP1 (0.56) | KEAP1NFE2L2CTSBKDM4EALDH1A1 | |
| SCHEMBL17612896 | 0.90 | KEAP1 (0.62) | KEAP1NFE2L2SMN1; SMN2NOTUM | |
| SCHEMBL17599508 | 0.90 | KEAP1 (0.62) | KEAP1NFE2L2SMN1; SMN2NOTUM | |
| SCHEMBL17599497 | 0.83 | KEAP1 (0.75) | KEAP1NFE2L2CTSBTDP1MMP2 | |
| SCHEMBL17599448 | 0.80 | KEAP1 (0.73) | KEAP1NFE2L2CTSBTDP1MMP2 | |
| SCHEMBL17612884 | 0.80 | KEAP1 (1.00) | KEAP1NFE2L2CTSBTDP1MMP2 | |
| SCHEMBL17599451 | 0.80 | KEAP1 (1.00) | KEAP1NFE2L2CTSBTDP1MMP2 | |
| SCHEMBL17599418 | 0.80 | KEAP1 (1.00) | KEAP1NFE2L2CTSBTDP1MMP2 | |
| SCHEMBL17599512 | 0.76 | KEAP1 (0.71) | KEAP1NFE2L2GAASMN1; SMN2NOTUM | |
| SCHEMBL17599511 | 0.76 | KEAP1 (0.71) | KEAP1NFE2L2GAASMN1; SMN2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997966-A1 | Naphthyl Sulfonamide Pyrrolidine Derivatives as KEAP-1 Modulators for the Treatment of Diabetes, Obesity, Dyslipidemia and Related Disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |