Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 7/20 | 0.73 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.58 |
| ▸ | ACLY | P53396 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 2/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | UQCRB | P14927 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599424 | 0.89 | KEAP1 (0.72) | KEAP1NFE2L2ACLYNOTUM | |
| SCHEMBL17599451 | 0.85 | KEAP1 (1.00) | KEAP1NFE2L2MMP2SLC40A1TDP1 | |
| SCHEMBL17612884 | 0.85 | KEAP1 (1.00) | KEAP1NFE2L2MMP2SLC40A1TDP1 | |
| SCHEMBL17599418 | 0.85 | KEAP1 (1.00) | KEAP1NFE2L2MMP2SLC40A1TDP1 | |
| SCHEMBL17599497 | 0.83 | KEAP1 (0.75) | KEAP1NFE2L2ACLYMMP2SLC40A1 | |
| SCHEMBL17612898 | 0.82 | KEAP1 (0.55) | KEAP1NFE2L2ALDH1A1CTSBNOTUM | |
| SCHEMBL17599504 | 0.81 | KEAP1 (0.65) | KEAP1NFE2L2MMP2SLC40A1KDM4E | |
| SCHEMBL17599464 | 0.80 | KEAP1 (0.66) | KEAP1NFE2L2MMP2SLC40A1TDP1 | |
| SCHEMBL17599439 | 0.80 | KEAP1 (0.90) | KEAP1NFE2L2MMP2SLC40A1TDP1 | |
| SCHEMBL24812743 | 0.78 | KEAP1 (0.87) | KEAP1NFE2L2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997966-A1 | Naphthyl Sulfonamide Pyrrolidine Derivatives as KEAP-1 Modulators for the Treatment of Diabetes, Obesity, Dyslipidemia and Related Disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |