Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 7/20 | 0.65 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | CCR10 | P46092 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.37 |
| ▸ | UQCRB | P14927 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | PKLR | P30613 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599501 | 0.88 | KEAP1 (0.62) | KEAP1NFE2L2BRD4CCR10DRD2 | |
| SCHEMBL17599448 | 0.81 | KEAP1 (0.73) | KEAP1NFE2L2KDM4EMMP2SLC40A1 | |
| SCHEMBL17599495 | 0.81 | KEAP1 (0.63) | KEAP1NFE2L2BRD4KDM4EMMP2 | |
| SCHEMBL17599418 | 0.79 | KEAP1 (1.00) | KEAP1NFE2L2KDM4EMMP2SLC40A1 | |
| SCHEMBL17612884 | 0.79 | KEAP1 (1.00) | KEAP1NFE2L2KDM4EMMP2SLC40A1 | |
| SCHEMBL17599451 | 0.79 | KEAP1 (1.00) | KEAP1NFE2L2KDM4EMMP2SLC40A1 | |
| SCHEMBL17599497 | 0.77 | KEAP1 (0.75) | KEAP1NFE2L2KDM4EMMP2SLC40A1 | |
| SCHEMBL17599461 | 0.74 | KEAP1 (0.65) | KEAP1NFE2L2KDM4EMMP2SLC40A1 | |
| SCHEMBL17599439 | 0.74 | KEAP1 (0.90) | KEAP1NFE2L2KDM4EMMP2SLC40A1 | |
| SCHEMBL17599464 | 0.73 | KEAP1 (0.66) | KEAP1NFE2L2BRD4KDM4EMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997966-A1 | Naphthyl Sulfonamide Pyrrolidine Derivatives as KEAP-1 Modulators for the Treatment of Diabetes, Obesity, Dyslipidemia and Related Disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |