Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | S100A4 | P26447 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599445 | 0.84 | ALDH1A1 (0.55) | KMT2AALDH1A1MAPTMEN1HTT | |
| SCHEMBL17599469 | 0.81 | ALDH1A1 (0.69) | KMT2AALDH1A1MAPTPOLBMEN1 | |
| SCHEMBL3435049 | 0.81 | ALDH1A1 (0.70) | KMT2AALDH1A1MAPTPOLBMEN1 | |
| SCHEMBL21848210 | 0.78 | MAPT (0.74) | KMT2AALDH1A1MAPTPOLBMEN1 | |
| SCHEMBL31175186 | 0.78 | ALDH1A1 (0.70) | KMT2AALDH1A1HTTCYP2C19KDM4E | |
| SCHEMBL2390380 | 0.77 | MAPT (0.63) | KMT2AALDH1A1MAPTPOLBMEN1 | |
| SCHEMBL17599548 | 0.76 | NPSR1 (0.53) | KMT2AALDH1A1MAPTMEN1HTT | |
| SCHEMBL16880599 | 0.75 | MAPT (0.58) | KMT2AALDH1A1MAPTPOLBMEN1 | |
| SCHEMBL28360511 | 0.75 | MAPT (0.58) | KMT2AALDH1A1MAPTPOLBMEN1 | |
| SCHEMBL30608491 | 0.74 | ALDH1A1 (0.55) | KMT2AALDH1A1MAPTPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998292-A1 | Naphthyl sulfonamide derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |
| EP-2998292-A1 | Naphthyl sulfonamide derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |