Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | RAD52 | P43351 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8127203 | 0.92 | HDAC2 (0.72) | ALDH1A1SMN1; SMN2LMNAMAPTGAA | |
| SCHEMBL3112471 | 0.87 | MAPT (0.60) | ALDH1A1SMN1; SMN2LMNAMAPTGAA | |
| SCHEMBL16227646 | 0.86 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2LMNAMAPTGAA | |
| SCHEMBL3034681 | 0.85 | ALDH1A1 (0.72) | ALDH1A1SMN1; SMN2GAATSHRKDM4E | |
| SCHEMBL178534 | 0.84 | KMT2A (0.71) | ALDH1A1SMN1; SMN2LMNAMAPTGAA | |
| SCHEMBL19226707 | 0.82 | SMN1; SMN2 (0.92) | ALDH1A1SMN1; SMN2LMNAMAPTGAA | |
| SCHEMBL12074931 | 0.81 | LMNA (0.92) | ALDH1A1SMN1; SMN2LMNAMAPTGAA | |
| SCHEMBL12132533 | 0.81 | LMNA (0.64) | ALDH1A1SMN1; SMN2LMNAMAPTGAA | |
| SCHEMBL4150303 | 0.81 | LMNA (0.50) | ALDH1A1SMN1; SMN2LMNAMAPTGAA | |
| SCHEMBL19891358 | 0.80 | DRD2 (0.62) | ALDH1A1SMN1; SMN2LMNAMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091527-B1 | SULFIDE, SULFOXIDE AND SULFONE CHALCONE ANALOGUES, DERIVATIVES THEREOF AND THERAPEUTIC USES THEREOF | UNIV TEMPLE (US) | 2016-03-23 | — | — | EP | disclosed |