Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24482984 | 0.86 | MEN1 (0.47) | KDM4EALDH1A1MAPTNPC1GAA | |
| SCHEMBL17600647 | 0.84 | ALDH1A1 (0.57) | KDM4EALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL2204971 | 0.83 | KMT2A (0.56) | KDM4EALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL22346686 | 0.83 | ALOX15 (0.59) | KDM4EALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL829961 | 0.83 | ALDH1A1 (0.71) | KDM4EALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL18531909 | 0.82 | GAA (0.63) | KDM4EALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL1356850 | 0.81 | ALDH1A1 (0.70) | KDM4EALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL39909 | 0.81 | ALDH1A1 (0.66) | KDM4EALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL6824483 | 0.79 | MEN1 (0.54) | KDM4EALDH1A1MAPTRAB9AGAA | |
| SCHEMBL8795255 | 0.79 | ALOX15 (0.57) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9572794-B2 | Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists | VANDERBILT UNIVERSITY (US) | 2017-02-21 | — | — | US | disclosed |
| US-9572794-B2 | Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists | VANDERBILT UNIVERSITY (US) | 2017-02-21 | — | — | US | disclosed |
| US-9572794-B2 | Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists | VANDERBILT UNIVERSITY (US) | 2017-02-21 | — | — | US | disclosed |
| US-20160083363-A1 | Substituted Indoles as Selective Protease Activated Receptor 4 (PAR-4) Antagonists | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-03-24 | — | — | US | disclosed |
| US-20160083363-A1 | Substituted Indoles as Selective Protease Activated Receptor 4 (PAR-4) Antagonists | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-03-24 | — | — | US | disclosed |
| US-20160083363-A1 | Substituted Indoles as Selective Protease Activated Receptor 4 (PAR-4) Antagonists | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160083363-A1 | Substituted Indoles as Selective Protease Activated Receptor 4 (PAR-4) Antagonists | F2RL3, F2R, F2RL1 | KDM4E 962/4885ALDH1A1 3242/4885MAPT 3361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.