Sugi Predict

Sugi Predict / Compounds / SCHEMBL17602140

SCHEMBL17602140

SCHEMBL17602140

CC(C)(C)[Si](C)(C)Oc1ccc2c(c1)CCCN2

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HRH3 Q9Y5N1 2/20 0.45
▸ CA12 O43570 5/20 0.44
▸ CA1 P00915 5/20 0.44
▸ CA9 Q16790 5/20 0.44
▸ CA2 P00918 1/20 0.44
▸ MAPT P10636 3/20 0.43
▸ KDM4E B2RXH2 2/20 0.43
▸ GAA P10253 2/20 0.43
▸ ALDH1A1 P00352 1/20 0.43
▸ LMNA P02545 1/20 0.43
▸ TP53 P04637 1/20 0.43
▸ THRB P10828 1/20 0.43
▸ ALOX15 P16050 1/20 0.43
▸ CASP1 P29466 1/20 0.43
▸ HTT P42858 1/20 0.43
▸ CASP7 P55210 1/20 0.43
▸ HSD17B10 Q99714 1/20 0.43
▸ TDP1 Q9NUW8 1/20 0.43
▸ PREP P48147 1/20 0.38
▸ CYP11B2 P19099 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2996673 0.89 HRH3 (0.45) HRH3CA12CA1CA9MAPT
SCHEMBL16468347 0.78 DRD2 (0.37) HRH3CA12CA1CA9PREP
SCHEMBL665048 0.77 CA12 (0.53) HRH3CA12CA1CA9CA2
Hydrochloric Acid SCHEMBL8021718 0.75 KDM4E (0.53) HRH3CA12CA1CA9CA2
SCHEMBL15052448 0.74 ALDH1A1 (0.53) CA12CA1CA9MAPTKDM4E
SCHEMBL27510896 0.73 KDM4E (0.51) HRH3CA12CA1CA9CA2
SCHEMBL10909390 0.73 KDM4E (0.50) HRH3CA12CA1CA9CA2
SCHEMBL3711357 0.73 HRH3 (0.49) HRH3CA12CA1CA9CA2
SCHEMBL10911483 0.73 HRH3 (0.59) HRH3CA12CA1CA9CA2
SCHEMBL29175231 0.72 PARP10 (0.52) CA12CA1CA9PREP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250066355-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. (US) 2025-02-27 — — US disclosed
US-12172998-B2 Histone demethylase inhibitors CELGENE QUANTICEL RESEARCH, INC. (US) 2024-12-24 — — US disclosed
US-12138263-B2 Pyrazolo[3,4-b]pyrazine SHP2 phosphatase inhibitors and methods of use thereof RELAY THERAPEUTICS, INC. (US) 2024-11-12 — — US disclosed
US-20230117519-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. (US) 2023-04-20 — — US disclosed
US-20230117519-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. (US) 2023-04-20 — — US disclosed
US-11535616-B2 Histone demethylase inhibitors CELGENE QUANTICEL RESEARCH, INC (US) 2022-12-27 — — US disclosed
US-11535616-B2 Histone demethylase inhibitors CELGENE QUANTICEL RESEARCH, INC (US) 2022-12-27 — — US disclosed
EP-3453710-B1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RES INC (US) 2022-09-21 — — EP disclosed
EP-3430008-B1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RES INC (US) 2022-05-18 — — EP disclosed
EP-3430008-B1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RES INC (US) 2022-05-18 — — EP disclosed
US-9643965-B2 Histone demethylase inhibitors Celgene Quantical Research, Inc. (US) 2017-05-09 — — US disclosed
US-9643965-B2 Histone demethylase inhibitors Celgene Quantical Research, Inc. (US) 2017-05-09 — — US disclosed
US-20160194323-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. 2016-07-07 — — US disclosed
US-20160194323-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. 2016-07-07 — — US disclosed
US-20160194323-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. 2016-07-07 — — US disclosed
WO-2016044429-A1 HISTONE DEMETHYLASE INHIBITORS Quanticel Pharmaceuticals, Inc. (US) 2016-03-24 — — WO disclosed
US-20160083379-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. 2016-03-24 — — US disclosed
WO-2016044429-A1 HISTONE DEMETHYLASE INHIBITORS Quanticel Pharmaceuticals, Inc. (US) 2016-03-24 — — WO disclosed
US-20160083379-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. 2016-03-24 — — US disclosed
US-20160083379-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. 2016-03-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160194323-A1 HISTONE DEMETHYLASE INHIBITORS KDM1B, KDM5C, KDM1A HRH3 437/4885CA12 3840/4885CA1 3047/4885
US-12172998-B2 Histone demethylase inhibitors KDM1B, KDM1A, KDM5C HRH3 433/4885CA12 3823/4885CA1 2987/4885
US-20160083379-A1 HISTONE DEMETHYLASE INHIBITORS KDM1B, KDM1A, KDM5C HRH3 433/4885CA12 3823/4885CA1 2987/4885
US-11535616-B2 Histone demethylase inhibitors KDM1B, KDM1A, KDM5C HRH3 433/4885CA12 3823/4885CA1 2987/4885
US-20230117519-A1 HISTONE DEMETHYLASE INHIBITORS KDM1B, KDM1A, KDM5C HRH3 433/4885CA12 3823/4885CA1 2987/4885
US-12138263-B2 Pyrazolo[3,4-b]pyrazine SHP2 phosphatase inhibitors and methods of use thereof PTPN2, PTPN5, PTPRJ HRH3 4380/4885CA12 3671/4885CA1 3749/4885
US-20250066355-A1 HISTONE DEMETHYLASE INHIBITORS KDM1B, KDM1A, KDM5C HRH3 433/4885CA12 3823/4885CA1 2987/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.