Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Benzimidazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.44 |
| ▸ | WNT3A | P56704 | 1/20 | 0.44 |
| ▸ | QPCT | Q16769 | 1/20 | 0.44 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CASP6 | P55212 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzimidazole SCHEMBL4969244 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2RAB9AKDM4EALDH1A1HPGD | |
| Benzimidazole SCHEMBL31595948 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2RAB9AKDM4EALDH1A1HPGD | |
| Benzimidazole SCHEMBL15092883 | 0.92 | RAB9A (0.45) | SMN1; SMN2RAB9AKDM4EALDH1A1HPGD | |
| Benzimidazole SCHEMBL28459336 | 0.92 | RAB9A (0.45) | SMN1; SMN2RAB9AKDM4EALDH1A1HPGD | |
| Benzimidazole SCHEMBL28471251 | 0.92 | RAB9A (0.45) | SMN1; SMN2RAB9AKDM4EALDH1A1HPGD | |
| Benzimidazole SCHEMBL28467053 | 0.92 | RAB9A (0.45) | SMN1; SMN2RAB9AKDM4EALDH1A1HPGD | |
| Benzimidazole SCHEMBL7068655 | 0.92 | SMN1; SMN2 (0.45) | SMN1; SMN2RAB9AKDM4EALDH1A1HPGD | |
| Benzimidazole SCHEMBL28462564 | 0.92 | RAB9A (0.45) | SMN1; SMN2RAB9AKDM4EALDH1A1HPGD | |
| Pyrophosphoric Acid SCHEMBL28258905 | 0.89 | SMN1; SMN2 (0.43) | SMN1; SMN2RAB9AKDM4EALDH1A1HPGD | |
| Benzimidazole SCHEMBL28459334 | 0.88 | SMN1; SMN2 (0.46) | SMN1; SMN2RAB9AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110407815-A | A kind of phosphatic preparation of benzimidazole, structure and photoluminescent property | UNIV QILU TECHNOLOGY | 2019-11-05 | — | — | CN | claimed |
| CN-106410247-A | Polybenzimidazole phosphoric acid high-temperature proton exchange membrane with high phosphoric acid adsorbing capability and preparation method thereof | 黄河科技学院 | 2017-02-15 | — | — | CN | claimed |
| CN-103490081-B | Modification perfluorosulfonic acid proton exchange film, its preparation method and direct methanol fuel cell membrane electrode and preparation method thereof | CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY CHINESE ACADEMY OF SCIENCES (CN) | 2016-01-20 | — | — | CN | claimed |
| CN-103490081-A | Modified nafion proton exchange membrane, preparation method of proton exchange membrane, direct methanol fuel cell membrane electrode and preparation method of membrane electrode | CHANGCHUN APPLIED CHEMISTRY | 2014-01-01 | — | — | CN | claimed |
| CN-119663512-A | Preparation method of high-elasticity high-strength spandex fiber fabric | 普宁市大可纺织有限公司 | 2025-03-21 | — | — | CN | disclosed |
| CN-105895944-B | Preparation method of sulfur-containing polybenzimidazole proton exchange membrane | 北京化工大学 | 2021-06-08 | — | — | CN | disclosed |
| US-10991966-B1 | Doped polymer electrolytes and methods of making and using the same | TRIAD NATIONAL SECURITY, LLC (US) | 2021-04-27 | — | — | US | disclosed |
| US-20200321642-A1 | PHYTIC ACID BASED METALLOGEL AND APPLICATIONS THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2020-10-08 | — | — | US | disclosed |
| US-10658690-B2 | Phytic acid based metallogel and applications thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2020-05-19 | — | — | US | disclosed |
| CN-106015955-B | Lighting device | 现代摩比斯株式会社 | 2019-11-19 | — | — | CN | disclosed |
| CN-110407815-A | A kind of phosphatic preparation of benzimidazole, structure and photoluminescent property | UNIV QILU TECHNOLOGY | 2019-11-05 | — | — | CN | disclosed |
| EP-3180814-B1 | PHYTIC ACID BASED METALLOGEL AND APPLICATIONS THEREOF | COUNCIL SCIENT IND RES (IN) | 2019-04-03 | — | — | EP | disclosed |
| CN-101454933-A | Method for producing a membrane electrode unit for a fuel cell | BASF SE (DE) | 2009-06-10 | — | — | CN | disclosed |
| CN-101288192-A | Method for producing membranes coated with a catalyst on both sides | BASF SE (DE) | 2008-10-15 | — | — | CN | disclosed |
| WO-2006080766-A1 | ACID OR BASE-DOPED PROTON CONDUCTING POLYMER, PREPARATION METHOD THEREOF, POLYMER MEMBRANE USING THE SAME AND FUEL CELL USING THE SAME | INDUSTRY-UNIVERSITY COOPERATION FOUNDATION, HANYANG UNIVERSITY (KR) | 2006-08-03 | — | — | WO | disclosed |
| CN-1809941-A | Fuel cell cartridge for portable electronic device | POLYFUEL INC (US) | 2006-07-26 | — | — | CN | disclosed |
| US-20060141316-A1 | Proton conductor and electrochemical device using the same | SAMSUNG SDI CO., LTD. | 2006-06-29 | — | — | US | disclosed |
| CN-1439032-A | Polymer composition | STANFORD RES INST INT (US) | 2003-08-27 | — | — | CN | disclosed |
| CN-1346707-A | Fluoric proton exchange resins of polytrifluorostyrenes, synthesizing process and application thereof | SHANGHAI INST ORGANIC CHEM (CN) | 2002-05-01 | — | — | CN | disclosed |
| CN-1297463-A | Acid-base polymer blends and use in membrane processes | UNIV STUTTGART (DE) | 2001-05-30 | — | — | CN | disclosed |