Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1C | Q14123 | 2/20 | 0.50 |
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
| ▸ | PDE1A | P54750 | 1/20 | 0.50 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.50 |
| ▸ | PDE9A | O76083 | 7/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17604145 | 0.84 | PDE1C (0.45) | PDE1CPDE5APDE1APDE1BPDE9A | |
| SCHEMBL17604369 | 0.75 | GRIA1 (0.58) | PDE1CPDE5APDE1APDE1BPDE9A | |
| SCHEMBL17604293 | 0.75 | PDE9A (0.73) | PDE1CPDE9AACHE | |
| SCHEMBL17604104 | 0.74 | ALDH1A1 (0.47) | PDE1CPDE5APDE1APDE1BPDE9A | |
| SCHEMBL14768701 | 0.71 | PDE5A (0.38) | PDE1CPDE5APDE1APDE1BADORA2A | |
| SCHEMBL14768666 | 0.64 | PDE5A (0.40) | PDE1CPDE5APDE1APDE1BHPGD | |
| SCHEMBL24165809 | 0.63 | PNP (0.41) | PDE1CPDE5APDE1APDE1BTSHR | |
| SCHEMBL21138862 | 0.63 | KDM1A (0.40) | PDE1CPDE5APDE1APDE1BADORA2A | |
| SCHEMBL21138340 | 0.63 | PDE5A (0.38) | PDE1CPDE5APDE1APDE1BHPGD | |
| SCHEMBL14709136 | 0.60 | KDM1A (0.58) | PDE1CPDE5APDE1APDE1BADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160083391-A1 | TRICYCLIC PIPERAZINE DERIVATIVE | SUNOVION PHARMACEUTICALS INC (US) | 2016-03-24 | — | — | US | disclosed |
| US-20160083391-A1 | TRICYCLIC PIPERAZINE DERIVATIVE | SUNOVION PHARMACEUTICALS INC (US) | 2016-03-24 | — | — | US | disclosed |
| US-20160083391-A1 | TRICYCLIC PIPERAZINE DERIVATIVE | SUNOVION PHARMACEUTICALS INC (US) | 2016-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160083391-A1 | TRICYCLIC PIPERAZINE DERIVATIVE | PDE3A, PDE5A, PDE2A | PDE1C 14/4885PDE5A 2/4885PDE1A 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.