Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.58 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.58 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.58 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.58 |
| ▸ | PDE5A | O76074 | 3/20 | 0.53 |
| ▸ | PDE1A | P54750 | 3/20 | 0.53 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.53 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.53 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.49 |
| ▸ | PI4KA | P42356 | 3/20 | 0.42 |
| ▸ | PI4K2B | Q8TCG2 | 3/20 | 0.42 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | PNP | P00491 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HCAR1 | Q9BXC0 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7430898 | 0.82 | GRIA1 (0.62) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL17604230 | 0.80 | GRIA1 (0.51) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL14743926 | 0.80 | GRIA1 (0.62) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL7431961 | 0.80 | GRIA1 (0.62) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL4522031 | 0.76 | GRIA1 (0.58) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL17604246 | 0.75 | PDE1C (0.50) | PDE5APDE1APDE1BPDE1CADORA2A | |
| SCHEMBL17604293 | 0.71 | PDE9A (0.73) | PDE1CPDE9A | |
| SCHEMBL30947415 | 0.69 | PDE1A (0.59) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL2520262 | 0.69 | HCAR1 (0.52) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL6473284 | 0.68 | ADORA2A (0.54) | GRIA1GRIA2GRIA3GRIA4PI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160083391-A1 | TRICYCLIC PIPERAZINE DERIVATIVE | SUNOVION PHARMACEUTICALS INC (US) | 2016-03-24 | — | — | US | disclosed |
| US-20160083391-A1 | TRICYCLIC PIPERAZINE DERIVATIVE | SUNOVION PHARMACEUTICALS INC (US) | 2016-03-24 | — | — | US | disclosed |
| US-20160083391-A1 | TRICYCLIC PIPERAZINE DERIVATIVE | SUNOVION PHARMACEUTICALS INC (US) | 2016-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160083391-A1 | TRICYCLIC PIPERAZINE DERIVATIVE | PDE3A, PDE5A, PDE2A | GRIA1 2687/4885GRIA2 3067/4885GRIA3 3277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.