Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 7/20 | 0.34 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | KDM6B | O15054 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KDM5A | P29375 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17604615 | 0.75 | NPY5R (0.44) | MAPK14 | |
| SCHEMBL17686564 | 0.70 | PHF8 (0.66) | MAPK14KDM4CPHF8KDM5BNR3C2 | |
| SCHEMBL17604534 | 0.70 | MAPK14 (0.46) | MAPK14MAPK13MAPK9MAPK12MAPK11 | |
| SCHEMBL16095046 | 0.69 | KDM4C (0.60) | KDM4CKDM5BKDM5A | |
| SCHEMBL30574759 | 0.68 | IDO1 (0.51) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL16095534 | 0.67 | KDM4C (0.62) | KDM4C | |
| SCHEMBL16095141 | 0.67 | KDM4C (0.61) | KDM4CPHF8KDM5A | |
| SCHEMBL19358820 | 0.67 | KDM5A (0.36) | KDM4CPHF8KDM5BKDM5A | |
| SCHEMBL105252 | 0.66 | RAB9A (0.40) | GSK3BMAPTMAPK1 | |
| SCHEMBL30574683 | 0.64 | CCR1 (0.34) | KDM5BKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3193881-A1 | HISTONE DEMETHYLASE INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016044342-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals, Inc. (US) | 2016-03-24 | — | — | WO | disclosed |