Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHF8 | Q9UPP1 | 7/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | PAK4 | O96013 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16095813 | 0.90 | PHF8 (0.39) | PHF8KDM4CMAPK1PTPN11P2RX7 | |
| SCHEMBL17604574 | 0.81 | PHF8 (0.37) | PHF8KDM4CMAPK1PIK3CDPIK3CA | |
| SCHEMBL16095079 | 0.81 | ADORA2A (0.39) | PHF8KDM4CKDM2AMAPK1 | |
| SCHEMBL17604563 | 0.79 | KDM5B (0.41) | PHF8KDM4CMEN1KMT2APIM1 | |
| SCHEMBL16095102 | 0.79 | PHF8 (0.41) | PHF8KDM4CTAAR1P2RX7 | |
| SCHEMBL27967633 | 0.78 | IDO1 (0.42) | MAPK1TAAR1PNMTMEN1KMT2A | |
| SCHEMBL16095001 | 0.77 | TAAR1 (0.44) | KDM4CTAAR1MEN1KMT2A | |
| SCHEMBL16095163 | 0.77 | KDM4C (0.62) | PHF8KDM4C | |
| SCHEMBL17604567 | 0.76 | PHF8 (0.42) | PHF8KDM4CMAPK1PIK3CAPIK3CB | |
| SCHEMBL27967666 | 0.76 | PNMT (0.41) | PIK3CDPIK3CAPIK3CBPIK3CGTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3193881-A1 | HISTONE DEMETHYLASE INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016044342-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals, Inc. (US) | 2016-03-24 | — | — | WO | disclosed |