Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK7 | Q13164 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17607239 | 0.76 | TMIGD3 (0.46) | MAPK7KDM1ARCOR1SCN9ATMIGD3 | |
| SCHEMBL20265732 | 0.75 | MAPK7 (0.82) | MAPK7 | |
| SCHEMBL2300600 | 0.75 | MAPK7 (0.48) | MAPK7NPC1RAB9A | |
| SCHEMBL4072949 | 0.73 | S1PR1 (0.49) | MAPK7TRPV1S1PR1S1PR3PIK3CA | |
| SCHEMBL17607174 | 0.72 | MAPK7 (0.58) | MAPK7KDM1ARCOR1SCN9ATMIGD3 | |
| SCHEMBL4068903 | 0.70 | NPC1 (0.51) | NPC1RAB9ATRPV1S1PR1PIK3CA | |
| SCHEMBL4063941 | 0.70 | S1PR1 (0.51) | MAPK7NPC1RAB9ATRPV1S1PR1 | |
| SCHEMBL4069506 | 0.69 | SMN1; SMN2 (0.54) | MAPK7NPC1RAB9ATRPV1S1PR1 | |
| SCHEMBL3345597 | 0.68 | NPC1 (0.48) | MAPK7NPC1RAB9A | |
| SCHEMBL5483909 | 0.67 | SMN1; SMN2 (0.53) | NPC1RAB9AGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3194390-A1 | PYRROLCARBOXAMIDE DERIVATIVES FOR THE INHBITION OF ERK5 | Cancer Research Technology Ltd (GB) | 2017-07-26 | — | — | EP | claimed |
| WO-2016042341-A1 | PYRROLCARBOXAMIDE DERIVATIVES FOR THE INHBITION OF ERK5 | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-03-24 | — | — | WO | claimed |