Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK7 | Q13164 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | PAICS | P22234 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17607206 | 0.88 | HIF1A (0.58) | MAPK7NPC1RAB9AGFERHIF1A | |
| SCHEMBL18083787 | 0.77 | CHRM3 (0.52) | MAPK7HIF1AEPAS1ACKR3MCHR1 | |
| SCHEMBL20265777 | 0.74 | MAPK7 (1.00) | MAPK7 | |
| SCHEMBL17607243 | 0.72 | MAPK7 (0.47) | MAPK7NPC1RAB9AGFERSCN9A | |
| SCHEMBL17607239 | 0.71 | TMIGD3 (0.46) | MAPK7NPC1RAB9AGFERSCN9A | |
| SCHEMBL18083686 | 0.71 | DGAT1 (0.56) | MAPK7HIF1AEPAS1MCHR1 | |
| SCHEMBL17239852 | 0.69 | HRH3 (0.46) | MAPK7HIF1AEPAS1MCHR1 | |
| SCHEMBL22085872 | 0.69 | HIF1A (0.46) | NPC1RAB9AHIF1AEPAS1 | |
| SCHEMBL3399676 | 0.69 | HIF1A (0.47) | MAPK7HIF1AEPAS1PAICSKDM5C | |
| SCHEMBL15251315 | 0.68 | KDM5C (0.52) | MAPK7HIF1AEPAS1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3194390-A1 | PYRROLCARBOXAMIDE DERIVATIVES FOR THE INHBITION OF ERK5 | Cancer Research Technology Ltd (GB) | 2017-07-26 | — | — | EP | claimed |
| WO-2016042341-A1 | PYRROLCARBOXAMIDE DERIVATIVES FOR THE INHBITION OF ERK5 | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-03-24 | — | — | WO | claimed |