Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1760747 | 0.92 | GYS1 (0.53) | GYS1 | |
| SCHEMBL1759549 | 0.90 | GYS1 (0.58) | GYS1 | |
| SCHEMBL1759606 | 0.86 | GYS1 (0.51) | GYS1 | |
| SCHEMBL1760786 | 0.85 | GYS1 (0.63) | GYS1 | |
| SCHEMBL1760807 | 0.83 | GYS1 (0.48) | GYS1TNF | |
| SCHEMBL1759704 | 0.79 | GYS1 (0.58) | GYS1 | |
| SCHEMBL1759720 | 0.78 | GYS1 (0.56) | GYS1 | |
| SCHEMBL1760810 | 0.78 | GYS1 (0.52) | GYS1 | |
| SCHEMBL1759662 | 0.76 | GYS1 (0.48) | GYS1 | |
| SCHEMBL1760803 | 0.76 | GYS1 (0.52) | GYS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947728-B1 | Indole and indazole analogs as glycogen synthase activators | HOFFMANN-LA ROCHE INC. (US) | 2011-05-24 | — | — | US | disclosed |
| US-20110112161-A1 | INDOLE AND INDAZOLE ANALOGS AS GLYCOGEN SYNTHASE ACTIVATORS | BOLIN DAVID ROBERT | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112161-A1 | INDOLE AND INDAZOLE ANALOGS AS GLYCOGEN SYNTHASE ACTIVATORS | GYS2, PYGL, GSK3B | GYS1 4/4885TNF 4515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.