Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 8/20 | 0.34 |
| ▸ | SHBG | P04278 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4409590 | 0.97 | KDM4E (0.38) | EPHX1TP53KDM4EGMNNLMNA | |
| Hydrochloric Acid SCHEMBL4416986 | 0.97 | KDM4E (0.38) | EPHX1TP53KDM4EGMNNLMNA | |
| SCHEMBL9387320 | 0.97 | — | — | |
| SCHEMBL538846 | 0.92 | — | — | |
| SCHEMBL7166980 | 0.86 | — | — | |
| SCHEMBL8926767 | 0.86 | — | — | |
| Hydrochloric Acid SCHEMBL2773491 | 0.83 | — | — | |
| SCHEMBL9887567 | 0.77 | EPHX1 (0.33) | EPHX1TP53KDM4EGMNNLMNA | |
| SCHEMBL7859411 | 0.75 | — | — | |
| SCHEMBL4019377 | 0.75 | DPP4 (0.33) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1125 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105899494-B | The Gd coordination compound of the conjugate of tranexamic acid containing DO3A- | 韩国庆北国立大学产业学术合作基金会 | 2018-06-15 | — | — | CN | claimed |
| US-20170027885-A1 | 1-AMINOCYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF COCHLEAR TINNITUS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2017-02-02 | — | — | US | claimed |
| US-9498450-B2 | 1-aminocyclohexane derivatives for the treatment of cochlear tinnitus | MERZ PHARMA GMBH & CO. KGAA (DE) | 2016-11-22 | — | — | US | claimed |
| US-9468610-B2 | 1-aminocyclohexane derivatives for the treatment of hearing loss | MERZ PHARMA GMBH & CO. KGAA (DE) | 2016-10-18 | — | — | US | claimed |
| US-8877814-B2 | Titration package for neramexane and its use in the treatment of an inner ear disorder | MERZ PHARMA GMBH & CO. KGAA (DE) | 2014-11-04 | — | — | US | claimed |
| US-20140228440-A1 | 1-AMINO-ALKYLCYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY SKIN DISEASES | MERZ PHARMA GMBH & CO. KGAA (DE) | 2014-08-14 | — | — | US | claimed |
| EP-2373304-B1 | Neramexane for the treatment of mast cell mediated diseases | MERZ PHARMA GMBH & CO KGAA (DE) | 2014-07-30 | — | — | EP | claimed |
| US-8680149-B2 | 1-amino-alkylcyclohexane derivatives for the treatment of mast cell mediated diseases | MERZ PHARMA GMBH & CO. KGAA (DE) | 2014-03-25 | — | — | US | claimed |
| US-20130158124-A1 | 1-AMINO-ALKYLCYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF MAST CELL MEDIATED DISEASES | MERZ PHARMA GMBH & CO. KGAA (DE) | 2013-06-20 | — | — | US | claimed |
| US-20130150449-A1 | 1-AMINO-ALKYLCYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY SKIN DISEASES | MERZ PHARMA GMBH & CO. KGAA (DE) | 2013-06-13 | — | — | US | claimed |
| EP-1228052-A1 | 1-CYCLIC AMINO-ALKYLCYCLOHEXANE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE AS ANTICONVULSANTS | Merz Pharmaceuticals GmbH (DE) | 2002-08-07 | — | — | EP | claimed |
| WO-2002024186-A1 | 1-AMINO-ALKYLCYCLOHEXANES AS TRYPANOCIDAL AGENTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2002-03-28 | — | — | WO | claimed |
| WO-2001098253-A2 | 1-AMINO-ALKYLCYCLOHEXANES AS 5-HT3 AND NEURONAL NICOTINICRECEPTOR ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2001-12-27 | — | — | WO | claimed |
| WO-2001032640-A1 | 1-CYCLIC AMINO-ALKYLCYCLOHEXANE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE AS ANTICONVULSANTS | MERZ PHARMACEUTICALS GMBH (DE) | 2001-05-10 | — | — | WO | claimed |
| CN-1266423-A | 1-amino-alkylcyclohexane NMDA receptor antagonists | MERZ & CO GMBH & CO (DE) | 2000-09-13 | — | — | CN | claimed |
| EP-1009732-A2 | 1-AMINO-ALKYLCYCLOHEXANE NMDA RECEPTOR ANTAGONISTS | MERZ + CO. GmbH & Co. (DE) | 2000-06-21 | — | — | EP | claimed |
| US-6071966-A | ADMINISTERING TO LIVING ANIMAL 1-AMINOALKYLCYCLOHEXANE COMPOUND FOR ALLEVIATION OF CONDITION WHICH IS ALLEVIATED BY N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST, OR FOR ITS IMMUNOMODULATORY, ANTIMALARIAL, ANTI-BORNA VIRUS EFFECTS | MERZ + CO. GMBH & CO. (DE) | 2000-06-06 | — | — | US | claimed |
| US-6034134-A | 1-Amino-alkylcyclohexane NMDA receptor antagonists | MERZ + CO. GMBH & CO. (DE) | 2000-03-07 | — | — | US | claimed |
| EP-0557046-B1 | Polymeric film | DU PONT (US) | 1999-12-01 | — | — | EP | claimed |
| WO-1999001416-A2 | 1-AMINO-ALKYLCYCLOHEXANE NMDA RECEPTOR ANTAGONISTS | MERZ + CO. GMBH & CO. (DE) | 1999-01-14 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150449-A1 | 1-AMINO-ALKYLCYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY SKIN DISEASES | NFKBIA, AADAC, LTA | EPHX1 1781/4885TP53 2249/4885KDM4E 2291/4885 |
| US-20170027885-A1 | 1-AMINOCYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF COCHLEAR TINNITUS | OTC, CNR2, CNR1 | EPHX1 3075/4885TP53 3642/4885KDM4E 3297/4885 |
| US-20140228440-A1 | 1-AMINO-ALKYLCYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY SKIN DISEASES | NFKBIA, AADAC, LTA | EPHX1 1781/4885TP53 2249/4885KDM4E 2291/4885 |
| US-20130158124-A1 | 1-AMINO-ALKYLCYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF MAST CELL MEDIATED DISEASES | CPA3, CMA1, MRGPRX1 | EPHX1 713/4885TP53 2528/4885KDM4E 1123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.