LTA — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL439382	1.00	2/20
SCHEMBL7903158	1.00	2/20
SCHEMBL29523045	1.00	2/20
SCHEMBL31196489	1.00	2/20
Water (SCHEMBL29459684)	0.97	2/20
SCHEMBL30889118	0.75	2/20
SCHEMBL38212	0.72	2/20
SCHEMBL38213	0.72	2/20
SCHEMBL29350628	0.72	2/20
SCHEMBL29351286	0.72	2/20
SCHEMBL2333709	0.71	2/20
SCHEMBL2415107	0.71	2/20
SCHEMBL29627175	0.71	2/20
SCHEMBL439381	0.70	2/20
SCHEMBL439383	0.70	2/20
SCHEMBL2286120	0.70	2/20
SCHEMBL15823889	0.70	2/20
SCHEMBL27168234	0.70	2/20
SCHEMBL31481692	0.70	2/20
SCHEMBL9094835	0.65	2/20

Clinical trials — most relevant to LTA by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Nitric Oxyde Concentration in Chronic Obstructive Pulmonary Disease Patients - SANOB Study	PHASE4	COMPLETED
Diet Rich in N-3 Polyunsaturated Fatty Acids in Renal Transplant Recipients	PHASE4	COMPLETED
Predicting Response to Standardized Pediatric Colitis Therapy	PHASE4	COMPLETED
Ramatroban/Montelukast Versus Montelukast/Placebo on the Early Allergic Reaction in Asthma Sensitive to House Dust Mite	PHASE2/PHASE3	WITHDRAWN
Triamcinolone Versus Methylprednisolone in Transversus Abdominis Plane Block	PHASE2/PHASE3	COMPLETED
Serum Intercellular Adhesion Molecule -1 in Acne Vulgaris Patients : Effect of Montelukast	PHASE3	UNKNOWN
Montelukast for Early Life Wheezing	PHASE2/PHASE3	COMPLETED
Gut-Liver Axis Modulation With IgG-Enriched Immunotherapy in Severe Alcohol-Associated Hepatitis	PHASE3	ACTIVE_NOT_RECRUITING
Etanercept in Hidradenitis Suppurativa	PHASE2	COMPLETED
The Controlled Trial of Apremilast for Rheumatoid Arthritis Treatment (CARAT)	PHASE2	COMPLETED
Lipid Infusion in Dialysis Patients With Endotoxemia	PHASE2	COMPLETED
Roflumilast in Non-CF Bronchiectasis Study	PHASE2	COMPLETED
GSK2190915 Neutrophilic Asthma Study	PHASE2	COMPLETED
Trial of Zileuton CR in Children and Adults With Sickle Cell Disease	PHASE1	COMPLETED
Point of Care Test of LTA Level in Tear Fluid, Measured With a POCT Test, in DE Patients Following IPL Treatment	nan	UNKNOWN
Leukotrienes Pathway in Chinese Children With Sleep-disordered Breathing	nan	UNKNOWN
Correlation of Genetic Susceptibility Genes to Inflammatory Bowel Disease in Chinese Han Population	nan	UNKNOWN
Modification of Allergic Immunologic Response by Leukotriene Antagonists - Ancillary to ACRN IMPACT	nan	COMPLETED
TL1A Inhibition in Systemic Sclerosis-Related Skin Fibrosis and Immunological Alterations: A Proof-of-Concept In Vitro Study (FIBROSTOP)	nan	NOT_YET_RECRUITING
TGF β 1 Expression Related Gene Polymorphism	nan	RECRUITING
Inflammatory Markers in Infants With Obstructive Sleep Apnea	nan	UNKNOWN
The Effectiveness of Montelukast on Atopic Dermatitis in Koreans	nan	COMPLETED
Evaluation of Salivary Biomarker Levels in Individuals With Different Periodontal Conditions	nan	COMPLETED
TL1A Expression in Psoriatic Skin	nan	UNKNOWN
Effect of Montelukast on the Expression and Variation of TGF-β for Children With Mild Persistent Asthma	nan	COMPLETED
Breath Condensate Study in Patients With Cystic Fibrosis.	nan	COMPLETED
Airborne Ultrafine and Fine Particulate Matter: A Cause for Endothelial Dysfunction in Man?	nan	COMPLETED
Characterization of Bronchiolitis-obliterans Syndrome (BOS) Following Lung Transplantation	nan	UNKNOWN
grouP O wholE blooD : storagE leSion impacT And infLammation	nan	RECRUITING
Novel Biomarkers in Inflammatory Bowel Disease	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a LTA binder may also engage these)

Protein	Name	Similarity
Q5TM20	—	1.000	Q5TM20 →
P61125	—	1.000	P61125 →
Q06332	—	0.998	Q06332 →
P09225	—	0.998	P09225 →
Q9JM09	—	0.996	Q9JM09 →
Q9XT48	—	0.995	Q9XT48 →
P26445	—	0.995	P26445 →
Q5WR07	—	0.994	Q5WR07 →
P10154	—	0.988	P10154 →
P32970	—	0.986	P32970 →
Q06600	—	0.986	Q06600 →
Q3ZDR4	—	0.985	Q3ZDR4 →
O75888	—	0.984	O75888 →
P19101	—	0.984	P19101 →
O55237	—	0.982	O55237 →
P59695	—	0.982	P59695 →
P04924	—	0.982	P04924 →
P48094	—	0.982	P48094 →
Q9BEA1	—	0.981	Q9BEA1 →
P33620	—	0.980	P33620 →
P51435	—	0.979	P51435 →
Q539C2	—	0.978	Q539C2 →
Q8MKG8	—	0.978	Q8MKG8 →
Q75N23	—	0.978	Q75N23 →
O77510	—	0.978	O77510 →
P29553	—	0.978	P29553 →
P51742	—	0.978	P51742 →
Q1WM27	—	0.977	Q1WM27 →
TNF	Tumor necrosis factor	0.977	landscape →
P79337	—	0.977	P79337 →