Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.45 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.44 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.44 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | STK32B | Q9NY57 | 1/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.44 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17610492 | 0.89 | IKBKB (0.49) | MGAMMAP4K4CSNK1G2CLK4MKNK2 | |
| SCHEMBL30315868 | 0.82 | ADORA1 (0.55) | ADORA2AADORA1CDC7 | |
| SCHEMBL31127610 | 0.79 | MGAM (0.57) | MGAMMAP4K4CSNK1G2CLK4MKNK2 | |
| SCHEMBL17799551 | 0.79 | MGAM (0.57) | MGAMMAP4K4CSNK1G2CLK4MKNK2 | |
| SCHEMBL17610507 | 0.78 | MGAM (0.54) | MGAMMAP4K4CSNK1G2CLK4MKNK2 | |
| SCHEMBL17610539 | 0.78 | HPGDS (0.43) | MGAMMAP4K4CSNK1G2CLK4MKNK2 | |
| SCHEMBL17610530 | 0.76 | MGAM (0.50) | MGAMMAP4K4CSNK1G2CLK4MKNK2 | |
| SCHEMBL17610545 | 0.75 | ADORA2A (0.68) | BMPR1BPIK3C2GCDKL5PIM1TYK2 | |
| SCHEMBL17610475 | 0.74 | HPGDS (0.50) | CLK4CLK2DYRK1A | |
| SCHEMBL856589 | 0.74 | ADORA1 (0.58) | BMPR1BPIK3C2GCDKL5PIM1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3193611-A2 | MK2 INHIBITORS AND USES THEREOF | CELGENE CAR LLC (BM) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016044463-A2 | MK2 INHIBITORS AND USES THEREOF | CELGENE AVILOMICS RESEARCH, INC. (US) | 2016-03-24 | — | — | WO | disclosed |