Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | HCK | P08631 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17610537 | 0.83 | HPGDS (0.45) | HPGDSMAP4K4JAK1JAK3DYRK1A | |
| SCHEMBL17610508 | 0.78 | MGAM (0.50) | MAP4K4DYRK1AALOX5APMTORPIK3CD | |
| SCHEMBL17610492 | 0.78 | IKBKB (0.49) | MAP4K4DYRK1AMTORMGAMCHEK1 | |
| SCHEMBL17610475 | 0.71 | HPGDS (0.50) | HPGDSDYRK1AHDAC1CLK4CLK2 | |
| SCHEMBL856589 | 0.68 | ADORA1 (0.58) | DYRK1AALOX5APBMPR1BPIK3C2GCDKL5 | |
| SCHEMBL17610545 | 0.66 | ADORA2A (0.68) | DYRK1AABL1MTORPIK3CDEGFR | |
| SCHEMBL14391613 | 0.65 | HDAC8 (0.43) | HPGDS | |
| SCHEMBL17610538 | 0.65 | MGAM (0.43) | HPGDSMAP4K4PIK3CDKDRMGAM | |
| SCHEMBL29818168 | 0.65 | PDGFRB (0.62) | MAP4K4DYRK1AMTORPIK3CDPIK3CA | |
| SCHEMBL531094 | 0.64 | HPGDS (0.72) | HPGDSCXCR4MGAMDPP4DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3193611-A2 | MK2 INHIBITORS AND USES THEREOF | CELGENE CAR LLC (BM) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016044463-A2 | MK2 INHIBITORS AND USES THEREOF | CELGENE AVILOMICS RESEARCH, INC. (US) | 2016-03-24 | — | — | WO | disclosed |