Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 13/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.58 |
| ▸ | DHFR | P00374 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.45 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.45 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | STK32B | Q9NY57 | 1/20 | 0.45 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.45 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29818168 | 0.82 | PDGFRB (0.62) | DHFRPDGFRBPDGFRACYP2A6BMPR1B | |
| SCHEMBL856588 | 0.82 | BMPR1B (0.49) | ADORA1ADORA2ADHFRPDGFRBPDGFRA | |
| SCHEMBL17610545 | 0.77 | ADORA2A (0.68) | ADORA1ADORA2APDGFRBPDGFRACYP2A6 | |
| SCHEMBL2624503 | 0.76 | PDGFRB (0.54) | DHFRPDGFRBPDGFRAKMT2ACYP2A6 | |
| SCHEMBL17610492 | 0.74 | IKBKB (0.49) | ADORA1ADORA2APDGFRBPDGFRACYP2A6 | |
| SCHEMBL17610508 | 0.74 | MGAM (0.50) | ADORA1ADORA2APDGFRBPDGFRAALOX5AP | |
| SCHEMBL2772360 | 0.74 | PDGFRB (0.77) | PDGFRBPDGFRACYP2A6 | |
| SCHEMBL32667946 | 0.74 | PDGFRB (0.77) | PDGFRBPDGFRACYP2A6 | |
| SCHEMBL4582424 | 0.73 | ADORA1 (0.83) | ADORA1ADORA2AGFERKMT2A | |
| SCHEMBL6985344 | 0.72 | POLB (0.57) | ADORA1ADORA2APDGFRBPDGFRACYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118087-B1 | PI 3-KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG (CH) | 2012-03-28 | — | — | EP | disclosed |