Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1761051 | 0.95 | MAPK1 (0.48) | ACHEMAPK1GAATSHRPOLB | |
| SCHEMBL1760859 | 0.87 | FAAH (0.50) | MAPK1FAAHALDH1A1MAPT | |
| Trifluoroacetic Acid SCHEMBL1761053 | 0.84 | FAAH (0.47) | GAAFAAHALDH1A1MEN1KMT2A | |
| SCHEMBL2931358 | 0.84 | NPSR1 (0.40) | MAPK1GAATSHRPOLBNPSR1 | |
| Trifluoroacetic Acid SCHEMBL1761006 | 0.83 | FAAH (0.39) | ACHEMAPK1TSHRPOLBFAAH | |
| Trifluoroacetic Acid SCHEMBL1760936 | 0.82 | PKM (0.40) | POLB | |
| SCHEMBL1760933 | 0.82 | FAAH (0.54) | FAAHALDH1A1MEN1KMT2A | |
| SCHEMBL1760981 | 0.81 | FAAH (0.49) | FAAHALDH1A1MEN1KMT2A | |
| SCHEMBL1761017 | 0.80 | CYP2D6 (0.44) | TSHRFAAHALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL1760939 | 0.80 | ADORA2A (0.39) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947692-B2 | Substituted thiazolo[5,4-d]pyrimidine urea derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-24 | — | — | US | disclosed |