Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrocortisone Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 9/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 10/20 | 0.69 |
| ▸ | PGR | P06401 | 2/20 | 0.69 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | AR | P10275 | 1/20 | 0.69 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | SHBG | P04278 | 1/20 | 0.67 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrocortisone Phosphoric Acid SCHEMBL42271 | 0.94 | HIF1A (0.77) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL19459282 | 0.94 | HIF1A (0.77) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL1761098 | 0.94 | HIF1A (0.77) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL21647387 | 0.94 | HIF1A (0.75) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL21313286 | 0.91 | HIF1A (0.81) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL6122495 | 0.90 | HIF1A (0.86) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL22982268 | 0.88 | HIF1A (0.77) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone SCHEMBL891448 | 0.87 | HIF1A (0.88) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL13026155 | 0.87 | HIF1A (0.78) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL7868481 | 0.87 | HIF1A (0.78) | HIF1APGRSERPINA6LMNAAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108699129-A | Single-stranded LIGHT receptor agonist proteins | 阿珀吉科吉尼科斯股份公司 | 2018-10-23 | — | — | CN | disclosed |
| CN-108473549-A | Single-stranded GITR receptor agonist proteins | 阿珀吉科吉尼科斯股份公司 | 2018-08-31 | — | — | CN | disclosed |
| CN-108430492-A | Single-stranded CD27 receptor agonist proteins | 阿珀吉科吉尼科斯股份公司 | 2018-08-21 | — | — | CN | disclosed |
| CN-108368511-A | Single-stranded CD137 receptor agonist proteins | 阿珀吉科吉尼科斯股份公司 | 2018-08-03 | — | — | CN | disclosed |