Hydrocortisone Phosphoric Acid

SCHEMBL21313286

C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO.C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)COP(=O)([O-])[O-].[Na+].[Na+]

nearest known ligand 0.81

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Hydrocortisone Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	3/20	0.81

▸	HIF1A	Q16665	12/20	0.81

▸	HSD17B10	Q99714	4/20	0.81

▸	SMN1; SMN2	Q16637	4/20	0.81

▸	NR3C2	P08235	4/20	0.81

▸	CYP2C19	P33261	3/20	0.81

▸	SERPINA6	P08185	3/20	0.81

▸	PGR	P06401	3/20	0.81

▸	CYP3A4	P08684	3/20	0.81

▸	KMT2A	Q03164	3/20	0.81

▸	NFKB1	P19838	2/20	0.81

▸	MAPT	P10636	2/20	0.81

▸	SHBG	P04278	2/20	0.81

▸	LMNA	P02545	3/20	0.72

▸	AR	P10275	1/20	0.72

▸	CHRM1	P11229	1/20	0.72

▸	PMP22	Q01453	2/20	0.70

▸	TSHR	P16473	2/20	0.70

▸	POLB	P06746	1/20	0.65

▸	GAA	P10253	1/20	0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Hydrocortisone Phosphoric Acid SCHEMBL1761098	0.97	HIF1A (0.77)	HIF1AHSD17B10SMN1; SMN2NR3C2CYP2C19
Hydrocortisone Phosphoric Acid SCHEMBL19459282	0.97	HIF1A (0.77)	HIF1AHSD17B10SMN1; SMN2NR3C2CYP2C19
Hydrocortisone Phosphoric Acid SCHEMBL42271	0.97	HIF1A (0.77)	HIF1AHSD17B10SMN1; SMN2NR3C2CYP2C19
Hydrocortisone Phosphoric Acid SCHEMBL22982268	0.96	HIF1A (0.77)	HIF1AHSD17B10SMN1; SMN2NR3C2CYP2C19
Hydrocortisone Phosphoric Acid SCHEMBL21647387	0.96	HIF1A (0.75)	HIF1AHSD17B10SMN1; SMN2NR3C2CYP2C19
Hydrocortisone SCHEMBL3098606	0.93	HIF1A (0.89)	HIF1AHSD17B10SMN1; SMN2NR3C2CYP2C19
Hydrocortisone SCHEMBL366439	0.93	HIF1A (0.89)	HIF1AHSD17B10SMN1; SMN2NR3C2CYP2C19
Hydrocortisone SCHEMBL2678895	0.93	HIF1A (0.89)	HIF1AHSD17B10SMN1; SMN2NR3C2CYP2C19
Hydrocortisone SCHEMBL42272	0.93	HIF1A (0.89)	HIF1AHSD17B10SMN1; SMN2NR3C2CYP2C19
Hydrocortisone SCHEMBL8584044	0.93	HIF1A (0.88)	HIF1AHSD17B10SMN1; SMN2NR3C2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-3532033-A1	PHARMACEUTICAL HYDROCORTISONE SOLUTION FOR AN INJECTION DEVICE	Crossject (FR)	2019-09-04	—	—	EP	claimed