Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 11/20 | 0.38 |
| ▸ | BCR | P11274 | 11/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.36 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.36 |
| ▸ | BRAF | P15056 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | HCK | P08631 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17612985 | 0.88 | BRAF (0.38) | ABL1BCRDDR1DDR2BRAF | |
| SCHEMBL12465079 | 0.86 | ABL1 (0.51) | ABL1BCR | |
| SCHEMBL12465084 | 0.80 | ABL1 (0.51) | ABL1BCR | |
| SCHEMBL17612913 | 0.80 | ABL1 (0.48) | ABL1BCRBRAFEGFR | |
| SCHEMBL13960452 | 0.79 | ABL1 (0.50) | ABL1BCR | |
| SCHEMBL12465299 | 0.78 | ABL1 (0.52) | ABL1BCR | |
| SCHEMBL13436419 | 0.78 | ABL1 (0.42) | ABL1BCR | |
| SCHEMBL12465093 | 0.78 | ABL1 (0.49) | ABL1BCR | |
| SCHEMBL12397808 | 0.78 | ABL1 (0.60) | ABL1BCR | |
| SCHEMBL17612946 | 0.77 | ABL1 (0.45) | ABL1BCRDDR2FLT1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173734-B1 | CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INT (DE) | 2016-03-23 | — | — | EP | disclosed |