Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.38 |
| ▸ | ABL1 | P00519 | 10/20 | 0.37 |
| ▸ | BCR | P11274 | 10/20 | 0.37 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.36 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 4/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | ARAF | P10398 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17612957 | 0.88 | ABL1 (0.38) | BRAFABL1BCRDDR1DDR2 | |
| SCHEMBL12464928 | 0.87 | ABL1 (0.49) | BRAFABL1BCR | |
| SCHEMBL17612910 | 0.82 | BRAF (0.40) | BRAF | |
| SCHEMBL12465298 | 0.80 | ABL1 (0.50) | ABL1BCR | |
| SCHEMBL12465144 | 0.79 | ABL1 (0.49) | ABL1BCR | |
| SCHEMBL12397841 | 0.79 | ABL1 (0.58) | ABL1BCR | |
| SCHEMBL12465082 | 0.79 | ABL1 (0.50) | ABL1BCR | |
| SCHEMBL17612913 | 0.78 | ABL1 (0.48) | BRAFABL1BCREGFR | |
| SCHEMBL12396860 | 0.78 | ABL1 (0.52) | ABL1BCR | |
| SCHEMBL17612996 | 0.77 | BRAF (0.40) | BRAFABL1BCRDDR1DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173734-B1 | CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INT (DE) | 2016-03-23 | — | — | EP | disclosed |