Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.40 |
| ▸ | PI4KA | P42356 | 2/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30527142 | 0.80 | CYP2A6 (0.50) | TRPV4 | |
| SCHEMBL17247906 | 0.80 | CYP2A6 (0.50) | TRPV4 | |
| SCHEMBL2858005 | 0.79 | KIF11 (0.55) | CYP2D6CYP19A1CYP2C9CYP2C19ABL1 | |
| SCHEMBL28863764 | 0.79 | ABL1 (0.48) | TRPV4MAPTKCNH2CYP2D6PIK3CA | |
| SCHEMBL30636554 | 0.78 | CYP2A6 (0.56) | TRPV4 | |
| SCHEMBL11541937 | 0.77 | CYP2D6 (0.60) | MAPTCYP2D6CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL20224611 | 0.77 | CYP2D6 (0.38) | MAPTCYP2D6CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL17247907 | 0.76 | CYP2A6 (0.53) | TRPV4KCNH2PIK3CAPI4KBMAP4K4 | |
| SCHEMBL28242951 | 0.76 | TRPV4 (0.42) | TRPV4KCNH2CYP2C19PIK3CAPI4KB | |
| SCHEMBL28021874 | 0.75 | KCNH2 (0.50) | TRPV4KCNH2PIK3CAPI4KBMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104869997-B | novel compounds as diacylglycerol acyltransferase inhibitors | 葛兰素史密斯克莱有限责任公司 | 2017-03-22 | — | — | CN | disclosed |
| WO-2016044792-A1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | HYDRA BIOSCIENCES, INC. (US) | 2016-03-24 | — | — | WO | disclosed |