Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | TOP1 | P11387 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11541937 | 0.83 | CYP2D6 (0.60) | CYP2D6CYP19A1CYP2C9CYP2C19NPY5R | |
| SCHEMBL12632461 | 0.81 | KIF11 (0.55) | KIF11CYP2D6CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL17619985 | 0.79 | TRPV4 (0.47) | CYP2D6CYP19A1CYP2C9CYP2C19ABL1 | |
| SCHEMBL30238069 | 0.79 | NPSR1 (0.43) | KIF11NPC1KDM1AMAOBTRPV1 | |
| SCHEMBL29683245 | 0.79 | CYP19A1 (0.52) | CYP2D6CYP19A1CYP2C9CYP2C19NPC1 | |
| SCHEMBL17246864 | 0.79 | CYP19A1 (0.52) | CYP2D6CYP19A1CYP2C9CYP2C19NPC1 | |
| SCHEMBL2406368 | 0.79 | IDO1 (0.54) | KIF11NPY5RKDM1AMAOBABL1 | |
| SCHEMBL5992577 | 0.78 | CYP2D6 (0.51) | CYP2D6CYP19A1CYP2C9CYP2C19CCNB2 | |
| Hydrochloric Acid SCHEMBL28429357 | 0.78 | IDO1 (0.53) | KIF11NPY5RKDM1AMAOBABL1 | |
| SCHEMBL4717978 | 0.77 | KIF11 (0.40) | KIF11CCNB2CDK1CCNB1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107709312-A | Novel antimalarial drug | 开普敦大学 | 2018-02-16 | — | — | CN | claimed |
| CN-110407816-B | Compound, application and device adopting compound | 清华大学 | 2021-08-13 | — | — | CN | disclosed |
| US-20200275655-A1 | PYRIDINIUM SALT AND PEST CONTROL AGENT | NIPPON SODA CO., LTD. (JP) | 2020-09-03 | — | — | US | disclosed |
| CN-108026050-A | NOVEL COMPOUNDS AS ROR GAMMA MODULATORS | 格兰马克药品股份有限公司 | 2018-05-11 | — | — | CN | disclosed |
| CN-107709312-A | Novel antimalarial drug | 开普敦大学 | 2018-02-16 | — | — | CN | disclosed |
| CN-107078217-A | Semiconductor composition comprising inorganic semiconductor material and organic bond | 默克专利股份有限公司 | 2017-08-18 | — | — | CN | disclosed |
| EP-2013171-B1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER S DISEASE | MERCK SHARP & DOHME (GB) | 2013-05-15 | — | — | EP | disclosed |
| US-8389547-B2 | Piperidines and related compounds for the treatment of Alzheimer's disease | MERCK SHARP & DOHME LLC | 2013-03-05 | — | — | US | disclosed |
| US-20100048623-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LLC | 2010-02-25 | — | — | US | disclosed |
| EP-1805141-B1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (GB) | 2010-01-20 | — | — | EP | disclosed |
| US-7638629-B2 | Piperidines and related compounds for treatment of alzheimer's disease | Merck Sharp & Dohme Ltd, (GB) | 2009-12-29 | — | — | US | disclosed |
| EP-2013171-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER S DISEASE | Merck Sharp & Dohme Limited (GB) | 2009-01-14 | — | — | EP | disclosed |
| US-20080021043-A1 | Piperidines and Related Compounds for Treatment of Alzheimer's Disease | MERCK SHARP & DOHME LTD. (GB) | 2008-01-24 | — | — | US | disclosed |
| WO-2007125364-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER’S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2007-11-08 | — | — | WO | disclosed |
| EP-1805141-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LTD. (GB) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006043064-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2006-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021043-A1 | Piperidines and Related Compounds for Treatment of Alzheimer's Disease | PSEN1, PSEN2, APP | KIF11 4413/4885CYP2D6 3883/4885CYP19A1 2824/4885 |
| US-20200275655-A1 | PYRIDINIUM SALT AND PEST CONTROL AGENT | PRDX1, KCNQ5, KCNQ1 | KIF11 3339/4885CYP2D6 776/4885CYP19A1 3249/4885 |
| US-20100048623-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | BACE1, PSEN1, BACE2 | KIF11 4104/4885CYP2D6 2952/4885CYP19A1 1422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.