Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4629836 | 0.88 | KMT2A (0.59) | KMT2AMEN1NOD2ALDH1A1NPC1 | |
| SCHEMBL2782915 | 0.82 | MEN1 (0.44) | KMT2AMEN1NOD2ADORA2AALDH1A1 | |
| SCHEMBL2782723 | 0.81 | ADORA2A (0.39) | KMT2AADORA2AALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL2780729 | 0.80 | PLAU (0.50) | ALDH1A1NPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL2782184 | 0.80 | AGTR1 (0.39) | KMT2AMEN1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL2780662 | 0.79 | ADRA2A (0.53) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL2777876 | 0.78 | SMN1; SMN2 (0.48) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL2380137 | 0.78 | ROCK2 (0.39) | KMT2AMEN1ALDH1A1MAPTGAA | |
| SCHEMBL2780849 | 0.77 | ADRA2A (0.50) | KMT2AMEN1ADORA2AALDH1A1NPC1 | |
| SCHEMBL2779998 | 0.77 | ROCK2 (0.42) | KMT2AMEN1ALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296697-B2 | Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-HT5-receptors | ABBOTT LABORATORIES (US) | 2016-03-29 | — | — | US | claimed |