Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17623259 | 0.86 | TP53 (0.42) | TP53MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL17623034 | 0.86 | TP53 (0.38) | KDM1ATP53MEN1KMT2AKDM4E | |
| SCHEMBL17622717 | 0.83 | MAPT (0.49) | MEN1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL1773880 | 0.83 | HRH4 (0.43) | TP53ACHEBACE1MEN1KMT2A | |
| SCHEMBL17623049 | 0.77 | ACACB (0.36) | TP53MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL1775125 | 0.76 | HRH4 (0.47) | ACHEBACE1MEN1KMT2AALDH1A1 | |
| SCHEMBL16091163 | 0.75 | TP53 (0.45) | TP53MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL17623058 | 0.73 | HRH4 (0.54) | KDM1AKDM4EALDH1A1HRH4CYP1A2 | |
| SCHEMBL16091174 | 0.72 | TP53 (0.43) | TP53MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL16090980 | 0.70 | TP53 (0.42) | KDM1ATP53MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016044641-A2 | CARM1 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2016-03-24 | — | — | WO | disclosed |