Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | TP53BP1 | Q12888 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CCR5 | P51681 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.44 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16152246 | 0.87 | SMN1; SMN2 (0.60) | GAATP53BP1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7719747 | 0.85 | EPHX2 (0.52) | NAMPTHDAC3ALDH1A1CA12CA1 | |
| SCHEMBL4968783 | 0.84 | GSK3B (0.50) | NAMPTGAAHDAC3GPR139ALDH1A1 | |
| SCHEMBL284884 | 0.83 | SMN1; SMN2 (0.59) | TP53BP1SMN1; SMN2CA12CA1CA2 | |
| SCHEMBL3900425 | 0.83 | CA12 (0.56) | SMN1; SMN2CA12CA1CA2CA9 | |
| SCHEMBL16151786 | 0.83 | SMN1; SMN2 (0.71) | GAATP53BP1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL14679385 | 0.83 | NPC1 (0.54) | GAAHDAC3TP53BP1SMN1; SMN2MAPT | |
| SCHEMBL284764 | 0.82 | SMN1; SMN2 (0.55) | GAAHDAC3TP53BP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5540070 | 0.82 | NAMPT (0.73) | NAMPTGAAMCHR1HDAC3SMN1; SMN2 | |
| SCHEMBL31407324 | 0.81 | TP53BP1 (0.70) | TP53BP1SMN1; SMN2ALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3196194-B1 | PYRIMIDINE DERIVATIVES USEFUL AS SELECTIVE JAK3 AND/OR JAK1 INHIBITORS | SHENZHEN CHIPSCREEN BIOSCIENCES LTD (CN) | 2019-08-07 | — | — | EP | disclosed |
| US-10011571-B2 | Preparation method for aromatic heterocyclic compound used as selective JAK3 and/or JAK1 kinase inhibitor and application of aromatic heterocyclic compound | SHENZHEN CHIPSCREEN BIOSCIENCES, LTD. (CN) | 2018-07-03 | — | — | US | disclosed |
| US-20170253566-A1 | PREPARATION METHOD FOR AROMATIC HETEROCYCLIC COMPOUND USED AS SELECTIVE JAK3 AND/OR JAK1 KINASE INHIBITOR AND APPLICATION OF AROMATIC HETEROCYCLIC COMPOUND | SHENZHEN CHIPSCREEN BIOSCIENCES, LTD. (CN) | 2017-09-07 | — | — | US | disclosed |
| EP-3196194-A1 | PREPARATION METHOD FOR AROMATIC HETEROCYCLIC COMPOUND USED AS SELECTIVE JAK3 AND/OR JAK1 KINASE INHIBITOR AND APPLICATION OF AROMATIC HETEROCYCLIC COMPOUND | Shenzhen Chipscreen Biosciences, Ltd. (CN) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016041472-A1 | PREPARATION METHOD FOR AROMATIC HETEROCYCLIC COMPOUND USED AS SELECTIVE JAK3 AND/OR JAK1 KINASE INHIBITOR AND APPLICATION OF AROMATIC HETEROCYCLIC COMPOUND | 深圳微芯生物科技有限责任公司 | 2016-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10011571-B2 | Preparation method for aromatic heterocyclic compound used as selective JAK3 and/or JAK1 kinase inhibitor and application of aromatic heterocyclic compound | JAK3, JAK1, JAK2 | NAMPT 2038/4885GAA 2845/4885MCHR1 1691/4885 |
| US-20170253566-A1 | PREPARATION METHOD FOR AROMATIC HETEROCYCLIC COMPOUND USED AS SELECTIVE JAK3 AND/OR JAK1 KINASE INHIBITOR AND APPLICATION OF AROMATIC HETEROCYCLIC COMPOUND | JAK3, JAK1, JAK2 | NAMPT 2038/4885GAA 2845/4885MCHR1 1691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.